GSK299115A

SKU: orb1700464

Description

GSK299115A is a potent and selective ROCK1 inhibitor with an IC50 of 8 nM, demonstrating significantly lower activity against RSK1 and p70S6K. This small molecule is a valuable research tool for investigating Rho-kinase signaling in cellular assays and has been utilized in studies exploring vascular function and fibrosis.

Research Area

Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 864082-35-9
• MW: 415.27
• Purity: 99.87%
• Formula: C₂₀H₁₆Cl₂N₄O₂
• SMILES: C(NC=1C=C2C(=CC1)NN=C2)(=O)C=3C(CC(=O)NC3C)C4=CC(Cl)=C(Cl)C=C4
• Target: GRK,PKA
• Solubility: DMSO:50 mg/mL (120.4 mM)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

GSK299115A, GSK-299115A, GSK 299115A, GRK2

Compound Identifiers

PubChem CID

11247002