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GSK269962A

SKU: orb1223034

Description

GSK269962 is a selective ROCK(Rho-associated protein kinase) inhibitor with IC50 values of 1.6 and 4 nM for ROCK1 and ROCK2, respectively.

Images & Validation

Key Properties

CAS Number850664-21-0
MW570.61
Purity>98% (HPLC)
FormulaC29H30N8O5
SMILESCCn1c2cc(ncc2nc1c1nonc1N)Oc1cccc(c1)NC(=O)c1ccc(cc1)OCCN1CCOCC1
TargetVEGFR
SolubilityDMSO : ≥ 30 mg/mL; 52.58 mM

Bioactivity

In Vivo
Animal model: Male Sprague-Dawley rats (350-400g). Dosage: 0.3, 1, and 3 mg/kg. Administration: Oral gavage; 12 hours. Result: Induced a dose-dependent reduction in blood pressure.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

GSK 269962

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Protocol Information

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200 mg
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$ 100.00
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100 mg
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