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GSK2643943A

SKU: orb1309604

Description

GSK2643943A is a potent and selective deubiquitylating enzyme (DUB) inhibitor targeting USP20 with an IC₅₀ of 160 nM. It exhibits anti-tumor activity and is a valuable chemical probe for researching ubiquitin signaling in cancer biology, both in cellular and in vivo models.

Research Area

Cell Biology, Molecular Biology, Protein Biochemistry

Images & Validation

Key Properties

CAS Number2449301-27-1
MW277.3
Purity97.09% (May vary between batches)
FormulaC17H12FN3
SMILESNc1[nH]c2cc(\C=C\c3cccc(F)c3)ccc2c1C#N
TargetDUB
SolubilityDMSO:125 mg/mL (450.78 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (14.42 mM)

Bioactivity

Target IC50
USP20/Ub-Rho:160 nM

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

GSK2643943A, GSK-2643943A, DUB, USP20/Ub-Rho

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Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

Protocol Information

Available Sizes

Select a size below

1 mg
$ 80.00
2 mg
$ 90.00
5 mg
$ 120.00
1 ml x 10 mM (in DMSO)
$ 130.00
10 mg
$ 170.00
25 mg
$ 310.00
50 mg
$ 440.00
100 mg
$ 640.00
200 mg
$ 890.00
DispatchUsually dispatched within 3-5 working days
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