Cart summary

You have no items in your shopping cart.

GSK256073

SKU: orb1217579

Description

GSK256073 is an orally active GPR109A agonist. GSK256073 also is a long-lasting and non-flushing HCA2 (hydroxy-carboxylic acid receptor 2) full agonist (pEC50: 7.5). GSK256073 acutely improves glucose homeostasis via inhibition of lipolysis.

Images & Validation

Key Properties

CAS Number862892-90-8
MW256.69
Purity>98% (HPLC)
FormulaC10H13ClN4O2
SMILESCCCCCN1C2=C(C(=O)NC1=O)NC(=N2)Cl
TargetGPR
SolubilityDMSO:16.67 mg/mL (64.94 mM; Need ultrasonic)

Bioactivity

In Vivo
Animal model: SD rat. Dosage: 1, 30 and 100 mg/kg. Administration: Oral adminstration. Result: Inhibited NEFA expression as a dose-dependent manner. Animal model: Guinea pigs. Dosage: 10 mg/kg. Administration: Intravenous injection. Result: Had the antilipolytic and flushing effects as a HCA2 agonist.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Similar Products

  • GSK256073 Tris [orb1738299]

    1228650-42-7

    377.826

    C14H24ClN5O5

    50 mg, 100 mg, 25 mg
  • GSK256073 [orb1308250]

    98.46% (May vary between batches)

    862892-90-8

    256.69

    C10H13ClN4O2

    5 mg, 10 mg, 50 mg, 100 mg, 25 mg, 2 mg, 1 ml x 10 mM (in DMSO), 1 mg
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Documents Download

Datasheet
Product Information
Download

Request a Document

Protocol Information

GSK256073 (orb1217579)

  • Star
  • Star
  • Star
  • Star
  • Star
  • 0.0
Based on 0 reviews

Participating in our Biorbyt product reviews program enables you to support fellow scientists by sharing your firsthand experience with our products.

Login to Submit a Review

No reviews yet

Step 1: Enter information below

(Recommended: An additional animal making an allowance for loss during the experiment)

Step 2: Enter the in vivo formulation

(This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

200 mg
500 mg
2 mg
$ 160.00
5 mg
$ 240.00
10 mg
$ 370.00
25 mg
$ 620.00
50 mg
$ 900.00
100 mg
$ 1,270.00