GSK2292767 FA

SKU: orb1819132

Description

GSK2292767 FA is a highly potent and selective PI3Kδ inhibitor (pIC50: 10.1) with >500-fold selectivity over other PI3K isoforms. It is a valuable research tool for investigating respiratory diseases, supporting both in vitro and in vivo studies of PI3Kδ-mediated pathways.

Research Area

Signal Transduction

Key Properties

• MW: 558.61
• Purity: 99.21% (May vary between batches)
• Formula: C₂₅H₃₀N₆O₇S
• SMILES: CS(NC1=CC(C2=CC(C3=NC=C(O3)CN4C[C@@H](O[C@@H](C4)C)C)=C5C(NN=C5)=C2)=CN=C1OC)(=O)=O.[H]C(O)=O
• Target: PI3K

Bioactivity

• In Vivo:
  GSK2292767 in a brown Norwegian rat acute OVA model of Th2 driven pulmonary inflammation in rats 35 μg/kg of ED50 protects eosinophil recruitment. In rat PK studies, GSK2292767 showed a high clearance rate (50 mL/min/kg) and low oral bioavailability (F<2%) in vivo.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

GSK2292767 FA, GSK2292767 FA(1254036-66-2 Free base), PI3Kδ

Compound Identifiers

PubChem CID

169553425