GSK2008607

SKU: orb1700479

Description

GSK2008607 is a potent and selective inhibitor of the B-RafV600E oncogenic mutant. It demonstrates robust antitumor activity in preclinical models, making it a valuable tool for in vitro and in vivo research into cancers driven by this mutation, such as melanoma, colorectal, and thyroid cancers.

Research Area

Signal Transduction

Key Properties

• CAS Number: 1244644-50-5
• MW: 667.72
• Purity: 99.99% (May vary between batches)
• Formula: C₃₁H₂₈F₃N₇O₃S₂
• SMILES: C(C)(C)C=1SC(=C(N1)C2=C(F)C(NS(=O)(=O)C3=C(F)C=CC=C3F)=CC=C2)C4=NC(NC=5C=CC(=NC5)N6CCOCC6)=NC=C4
• Target: Raf
• Solubility: DMSO:50 mg/mL (74.88 mM)

Bioactivity

• Target IC50:
  B-Raf:0.008 µM(EC50)|B-Raf:< 0.1 µM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

B-Raf (V600E), GSK 2008607, GSK2008607, GSK-2008607

Compound Identifiers

PubChem CID

56673516