GSK1370319A

SKU: orb1737810

Description

GSK1370319A is a potent and selective P2X7 receptor antagonist (IC50 = 3.2 nM) that blocks NLRP3 inflammasome assembly and IL-1β release in glial cells. It is a valuable research tool for studying neuroinflammation, demonstrating protective effects against neuronal loss in vitro and age-related synaptic deficits ex vivo.

Key Properties

• CAS Number: 1001389-31-6
• MW: 301.17
• Formula: C₁₃H₁₄Cl₂N₂O₂
• SMILES: C(NCC1=C(Cl)C=C(Cl)C=C1)(=O)[C@H]2N(C)C(=O)CC2
• Target: Others

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

67461788