GSK1362

SKU: orb3173052

Description

GSK1362 is a selective inverse agonist of REV-ERB. It disrupts the interaction between REV-ERBα and corepressors (NCoR1, SMRT2, RIP140). By enhancing the transcription of BMAL1, GSK1362 acts as an inverse agonist, counteracting endogenous REV-ERB ligands that inhibit BMAL1. GSK1362 suppresses the expression of inflammation factors induced by LPS and inhibits IL-1β-induced Cxcl5 transcription in cells. It is utilized in the study of inflammatory diseases.

Research Area

Metabolism Research

Key Properties

• CAS Number: 2986733-57-5
• MW: 396.88
• Formula: C₂₁H₂₁ClN₄O₂
• SMILES: N#CC=1N=C(OC1NCCOC)C=2C=CC(=CC2)N(C)CC3=CC=C(Cl)C=C3
• Target: REV-ERB

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

REV-ERB