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GSK1016790A

SKU: orb1221644

Description

GSK1016790A is a TRPV4 agonist that elicits calcium influx in HEK cells expressing mouse or human TRPV4 (EC50s = 18 and 2.1 nM, respectively).

Images & Validation

Key Properties

CAS Number942206-85-1
MW655.61
Purity>98% (HPLC)
FormulaC28H32Cl2N4O6S2
SMILESCC(C)C[C@H](NC(=O)C1=CC2=C(S1)C=CC=C2)C(=O)N1CCN(CC1)C(=O)[C@H](CO)NS(=O)(=O)C1=C(Cl)C=C(Cl)C=C1
TargetPI3K
SolubilityDMSO : ≥ 33 mg/mL; 50.33 mM

Bioactivity

In Vivo
Animal model: S100β-GFP and TRPV4 knockout (TRPV4-/-) mice. Dosage: 0.001, 0.01, 0.1 mg/kg. Administration: IP; single dose. Result: Produced a dose-dependent inhibitory effect on whole gut transit time in mice. Produced a dose-dependent and time-dependent inhibitory effect on colonic expulsion.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

GSK1016790A | GSK-1016790A | GSK 1016790A.

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    942206-85-1

    655.61

    C28H32Cl2N4O6S2

    5 mg, 10 mg, 25 mg, 2 mg, 100 mg, 1 mg, 1 ml x 10 mM (in DMSO), 50 mg
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Protocol Information

GSK1016790A (orb1221644)

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Step 1: Enter information below

(Recommended: An additional animal making an allowance for loss during the experiment)

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% DMSO +
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% Tween 80 +
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200 mg
500 mg
2 mg
$ 90.00
5 mg
$ 120.00
10 mg
$ 180.00
25 mg
$ 360.00
50 mg
$ 520.00
100 mg
$ 760.00