GSK0660

SKU: orb1223455

Description

GSK0660 is a selective PPARδ antagonist. GSK0660 differentially regulated 273 transcripts in TNFα-treated cells compared to TNFα alone. A pathway analysis revealed the enrichment of cytokine-cytokine receptor signaling. In particular, GSK0660 blocks the TNFα-induced upregulation of CCL8, a chemokine involved in leukocyte recruitment. GSK0660 blocks the effect of TNFα on the expressions of cytokines involved in leukocyte recruitment, including CCL8, CCL17, and CXCL10 and it may therefore block TNFα-induced retinal leukostasis.

Key Properties

• CAS Number: 1014691-61-2
• MW: 418.49
• Purity: >98% (HPLC)
• Formula: C₁₉H₁₈N₂O₅S₂
• SMILES: COc1c(ccc(c1)Nc1ccccc1)NS(=O)(=O)c1c(scc1)C(=O)OC
• Target: GluR
• Solubility: DMSO : ≥ 49 mg/mL 117.09 mM

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

GSK0660 | GSK-0660 | GSK 0660

Quick Database Links

Gene Symbol

GluR