GSK-LSD1 dihydrochloride

SKU: orb1305713

Description

GSK-LSD1 dihydrochloride is a potent and selective irreversible inhibitor of LSD1 (IC50 = 16 nM), demonstrating >1000-fold selectivity over related FAD-dependent enzymes like MAO-A/B. This inhibitor is a valuable chemical probe for investigating the role of LSD1 in epigenetic regulation, cancer biology, and other diseases in both cellular and animal models.

Research Area

Epigenetics & Chromatin, Neuroscience

Key Properties

• CAS Number: 2102933-95-7
• MW: 289.24
• Purity: 99.22%
• Formula: C₁₄H₂₂Cl₂N₂
• SMILES: Cl.Cl.C1[C@@H](NC2CCNCC2)[C@@H]1c1ccccc1
• Target: Monoamine Oxidase,Histone Demethylase
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.91 mM);DMSO:25 mg/mL (86.43 mM);H2O:50 mg/mL (172.87 mM)

Bioactivity

• Target IC50:
  LSD1:16 nM
• In Vitro:
  GSK-LSD1 induces gene expression changes in cancer cell lines with average EC50 of < 5 nM and inhibits cancer cell line growth with average EC50 of < 5 nM.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, LSD1, Inhibitor, Histone Demethylase, HistoneDemethylase, MAO, Monoamine Oxidase, GSK LSD1 dihydrochloride, GSK-LSD1, GSK-LSD1 (hydrochloride), GSK-LSD1 2HCl, GSKLSD1 dihydrochloride, GSK-LSD1 Dihydrochloride, GSK-LSD-1 dihydrochloride

Compound Identifiers

PubChem CID

91663353