GSK-A1

SKU: orb1305074

Description

GSK-A1 is a potent and selective PI4KA inhibitor that suppresses calcium-induced prolactin secretion without impacting calcium signaling or Prl gene expression. Its inhibition of the host PI4KA enzyme also confers promising anti-HCV activity, making it a valuable tool for studying phosphatidylinositol signaling and viral replication in vitro.

Research Area

Infectious Disease & Virology, Protein Biochemistry, Signal Transduction

Key Properties

• CAS Number: 1416334-69-4
• MW: 574.63
• Purity: 98.03%
• Formula: C₂₉H₂₇FN₆O₄S
• SMILES: COc1ncc(cc1S(=O)(=O)Nc1ccccc1F)-c1ccc2nc(N)n(-c3ccc(cc3)N3CCOCC3)c2c1
• Target: PI4K,HCV Protease
• Solubility: DMSO:2.3 mg/mL (4 mM)

Bioactivity

• Target IC50:
  PI4K2A:<5 (pIC50)|PI4KA:8.5-9.8 (pIC50)|PI4K2B:<5 (pIC50)|PI4KB:7.2-7.7 (pIC50)
• In Vitro:
  GSK-A1 is a selective type III phosphatidylinositol 4-kinase PI4KA (PI4KIIIα) inhibitor with a pIC50 of 8.5-9.8. GSK-A1 potently decreases the levels of PtdIns(4)P with a negligible effect on PtdIns(4,5)P2.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Hepatitis C virus, HCVProtease, HCV Protease, HCV, Inhibitor, GSK A1, GSKA1, GSK-A1, GSK-A-1, PI4KIIIα, PI4K, PI4 kinases, Phosphatidylinositol 4 kinases, phosphatidylinositol 4-kinase PI4KA, PtdIns(4)P, PtdIns(4,5)P2

Compound Identifiers

PubChem CID

71116366