GSK-5959

SKU: orb1306916

Description

GSK-5959 is a potent, selective, and cell-permeable small molecule inhibitor of the BRPF1 bromodomain, exhibiting an IC50 of approximately 80 nM. It demonstrates over 100-fold selectivity against 35 other bromodomains, including BRPF2/3 and BET family members. This inhibitor is a valuable chemical probe for investigating BRPF1 function in epigenetic regulation and related disease models in both cellular and in vivo contexts.

Research Area

Epigenetics & Chromatin

Key Properties

• CAS Number: 901245-65-6
• MW: 394.47
• Purity: 98.35% (May vary between batches)
• Formula: C₂₂H₂₆N₄O₃
• SMILES: COc1ccccc1C(=O)Nc1cc2n(C)c(=O)n(C)c2cc1N1CCCCC1
• Target: Epigenetic Reader Domain
• Solubility: DMSO:10 mg/mL (25.35 mM)

Bioactivity

• Target IC50:
  BRPF1:80 nM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

GSK 5959, GSK5959, GSK-5959, epigenetics, EpigeneticReaderDomain, Epigenetic Reader Domain, inhibit, Inhibitor, bromodomain, BRPF2, BRPF3, BRPF1, BRD1

Compound Identifiers

PubChem CID

15990224