GSK-583

SKU: orb1226485

Description

A potent, selective and orally bioavailable RIPK2 kinase inhibitor with IC50 of 5 nM and 2 nM for human and rat RIP2, respectively; displays robust selectivity against p38α and VEGFR2, and shows little or no inhibition of RIP3-dependent necroptotic cell death; potently and dose dependently inhibits MDP-stimulated TNFα production in human monocytes and human whole bolld with IC50 of 8 nM and 237 nM, respectively; inhibits MDP-induced inflammatory responses in vivo.

Key Properties

• CAS Number: 1346547-00-9
• MW: 398.4539
• Purity: >98% (HPLC)
• Formula: C₂₀H₁₉FN₄O₂S
• SMILES: FC1=CC2=C(NN=C2NC3=CC=NC4=CC=C(S(=O)(C(C)(C)C)=O)C=C34)C=C1
• Target: RIP kinase
• Solubility: DMSO: ≥ 37 mg/mL

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

GSK583 | GSK 583

Quick Database Links

Gene Symbol

RIP kinase