GSK-3α/β-IN-1

SKU: orb3027660

Description

GSK-3α/β-IN-1 is a GSK-3α/β inhibitor with IC50 values of 0.265 μM for GSK-3α and 0.255 μM for GSK-3β. It also inhibits PKA with an IC50 of 0.188 μM. GSK-3α/β-IN-1 effectively reduces cell viability in three glioblastoma (GBM) cell lines (IC50: 3-6 μM over 72 hours) without being toxic to human astrocytes, and it exhibits good metabolic stability. Additionally, it shows potential central nervous system activity in a whole human blood-brain barrier (BBB) GBM model.

Research Area

Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 1574354-24-7
• MW: 343.38
• Formula: C₂₁H₁₇N₃O₂
• SMILES: OC=1C=CC2=C(OC3=C2NC4=NN=CC4=C3C=5C=CC(=CC5)C(C)C)C1
• Target: PKA,GSK-3

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

PKA,GSK-3