GSK-2250665A

SKU: orb1700475

Description

GSK-2250665A is a potent and selective Itk inhibitor (pKi = 9.2) with >1000-fold selectivity over Aurora B and Btk. It suppresses IFNγ production in PBMCs, making it a valuable chemical probe for studying T-cell receptor signaling and immune modulation in both in vitro and in vivo immunological research.

Research Area

Signal Transduction

Key Properties

• CAS Number: 1246030-96-5
• MW: 459.61
• Purity: 99.38% (May vary between batches)
• Formula: C₂₆H₂₉N₅OS
• SMILES: N(C=1SC=2C(N1)=CC=C(CC)C2)C3=NC(N[C@H]4CC[C@H](O)CC4)=NC(CC5=CC=CC=C5)=C3
• Target: Tyrosine Kinases

Bioactivity

• Target IC50:
  Itk:9.2 (pKi)
• In Vitro:
  The pIC50 value of GSK-2250665A (Compound 13) for inhibiting IFNγ production in PBMCs is 7.3, as measured in a cell-based assay .

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

GSK 2250665, GSK 2250665A, GSK2250665, GSK-2250665, GSK2250665A

Compound Identifiers

PubChem CID

73352604