GS87

SKU: orb1298789

Description

GS87 is a potent and selective GSK3 inhibitor that promotes robust differentiation of acute myeloid leukemia (AML) cells. This small molecule is a valuable research tool for studying hematopoiesis, leukemogenesis, and differentiation therapy in both cellular and animal models of AML.

Research Area

Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 919936-70-2
• MW: 337.36
• Purity: 99.47% (May vary between batches)
• Formula: C₁₆H₁₁N₅O₂S
• SMILES: C(SC=1OC(=NN1)C=2C=CN=CC2)C3=NC(=NO3)C4=CC=CC=C4
• Target: GSK-3
• Solubility: DMSO:25 mg/mL (74.1 mM)

Bioactivity

• Target IC50:
  GSK-3β:521 nM|GSK-3α:415 nM
• In Vitro:
  GS87 potently inhibits growth of AML cells in mice with little effect on normal bone marrow cells. GS87 causes terminal differentiation of AML cells

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

differentiation, 4-[5-[[(3-Phenyl-1,2,4-oxadiazol-5-yl)methyl]thio]-1,3,4-oxadiazol-2-yl]pyridine, AML, Inhibitor, inhibit, MAPK, GSK3β, GSK3α, Glycogen synthase kinase-3, Glycogen synthase kinase 3, GS 87, GS87, GS-87, GSK-3, GSK3

Compound Identifiers

PubChem CID

17408143