Grp94 Inhibitor-2

SKU: orb2664137

Description

Grp94 Inhibitor-2 (compound 23) is a cyclopropane-containing small molecule that selectively binds Grp94 (Kd=0.48 µM) and Hsp90α (Kd=0.65 µM). This tool compound is used in vitro to study endoplasmic reticulum stress and protein folding pathways relevant to cancer and autoimmune disease research.

Research Area

Metabolism Research, Pharmacology & Drug Discovery; Cell Biology, Signal Transduction

Key Properties

• MW: 469.94
• Formula: C₂₆H₂₅ClFNO₄
• SMILES: FC(C=C1)=CC=C1CC2=CC=CC=C2CCC3=C(Cl)C(O)=CC(O)=C3C(N[C@@H]4C[C@@H](O)C4)=O
• Target: HSP

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

HSP