GRL-190-21

SKU: orb2566159

Description

GRL-190-21 (compound 5e), an inhibitor of SARS-Cov-2-Mpro, shows potent antiviral activity, with a K_i of 0.04 nM and an EC_50 of 0.26 μM in VeroE6 cells. It significantly reduces the infectivity, replication, and cytopathic effect of SARS-CoV-2 without notable toxicity.

Key Properties

• CAS Number: 2755957-14-1
• MW: 513.55
• Formula: C₂₄H₃₄F₃N₅O₄
• SMILES: C(N[C@@H](C[C@H]1C(=O)NCCC1)C#N)(=O)[C@@H]2[C@@]3([C@@](C3(C)C)(CN2C([C@@H](NC(C(F)(F)F)=O)[C@@](C)(C)C)=O)[H])[H]
• Target: SARS-CoV

Storage & Handling

• Storage: -20°C
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

SARS-CoV