GRI977143

SKU: orb1704505

Description

GRI977143 is a selective, non-lipid LPA2 receptor agonist with an EC50 of 3.3 µM. It functions as an anti-apoptotic agent by inhibiting caspases 3, 7, 8, and 9 and reducing DNA fragmentation, making it a useful research tool for studying lysophosphatidic acid signaling in models of cellular injury and survival.

Research Area

Cell Biology, Pharmacology & Drug Discovery, Protein Biochemistry

Key Properties

• CAS Number: 325850-81-5
• MW: 391.44
• Purity: 99.08% (May vary between batches)
• Formula: C₂₂H₁₇NO₄S
• SMILES: OC(=O)c1ccccc1SCCCN1C(=O)c2cccc3cccc(C1=O)c23
• Target: LPL Receptor,Caspase,LPA Receptor
• Solubility: DMSO:1 mg/mL (2.55 mM)

Bioactivity

• Target IC50:
  LPA2 receptor:3.3 μM (EC50)
• In Vitro:
  GRI977143 (10 μM) reduces caspase 3 and 7 activation by 51% in Doxorubicin-induced apoptotic signaling in vector-transduced or LPA2-transduced MEF. GRI977143 stimulates the activation of extracellular signal-regulated kinase 1/2 and promotes the assembly of LPA2, thyroid receptor-interacting protein 6 and Na+-H+ exchange regulatory factor 2.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

GRI 977143, GRI977143, GRI-977143, LPAReceptor, LPA Receptor, LPA2

Compound Identifiers

PubChem CID

3114900