GR 83074

SKU: orb1981012

Description

GR 83074 is a highly selective NK-2 receptor antagonist with a pK B of 8.23, exhibiting 340-fold selectivity over NK-1 and no activity at NK-3. This tool compound is widely used in vitro and in vivo to investigate the physiological roles of neurokinin signaling in processes like pain, inflammation, and gastrointestinal motility.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• Target: Neurokinin receptor
• CAS Number: 141636-44-4
• MW: 985.18
• Formula: C₅₀H₇₂N₁₂O₉
• SMILES: CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)OC(C)(C)C)C(N)=O

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

14991653