GR-73632

SKU: orb1296573

Description

This small molecule is a potent and selective agonist of the neurokinin 1 (NK1) receptor, exhibiting an EC50 of 2 nM in the guinea pig vas deferens assay. It is a valuable research tool for investigating the role of substance P signaling in pain, inflammation, and emesis through both in vitro and in vivo experimental models.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 133156-06-6
• MW: 766
• Purity: 99.68%
• Formula: C₄₀H₅₉N₇O₆S
• SMILES: CSCC[C@H](NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCCN)C(N)=O
• Target: Neurokinin receptor
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (2.61 mM);DMSO:10 mM

Storage & Handling

• Storage: keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Neurokinin receptor, Neurokinin Receptor, Neurokininreceptor, NK receptor, NK1, inhibit, Inhibitor, GR73632, GR-73632, GR 73632, Tachykinin receptor

Compound Identifiers

PubChem CID

119599