GPX4-IN-6

SKU: orb1962214

Description

GPX4-IN-6 is a potent covalent inhibitor of glutathione peroxidase 4 (GPX4) with an IC50 of 0.12 µM. It triggers ferroptosis and demonstrates antitumor activity, making it a valuable research tool for studying and targeting triple-negative breast cancer (TNBC) in both cellular and animal models.

Research Area

Cell Biology, Metabolism Research

Key Properties

• CAS Number: 2922824-07-3
• MW: 426.23
• Purity: 99.57% (May vary between batches)
• Formula: C₁₈H₁₇BrFNO₅
• SMILES: O=C(N(C1=CC=C2OCCOC2=C1)C3=CC(OC)=C(F)C(OC)=C3)CBr
• Target: Glutathione Peroxidase,GPX,Ferroptosis
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.69 mM);DMSO:30 mg/mL (70.38 mM)

Bioactivity

• Target IC50:
  GPX4:0.13 μM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

GPX4IN6, Gpx4

Compound Identifiers

PubChem CID

168510581