GPX4-IN-20

SKU: orb3175986

Description

GPX4-IN-20 is a derivative of Arctigenin and acts as a molecular glue degrader of GPX4, inducing ferroptosis by increasing lipid ROS levels and inhibiting GSH levels. It reduces the protein expression and enzyme activity of GPX4 in a dose-dependent manner without affecting other ferroptosis-related proteins. GPX4-IN-20 promotes ubiquitin-dependent proteasomal degradation of GPX4 and elevates malondialdehyde (MDA) levels in HCT-116 cells. This compound is applicable in colorectal cancer research.

Research Area

Cell Biology, Immunology & Inflammation, Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• Target: ROS,Molecular Glues,Glutathione Peroxidase,Ferroptosis

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

ROS,Molecular Glues,Glutathione Peroxidase,Ferroptosis