GPX4-IN-19

SKU: orb3134930

Description

GPX4-IN-19 is a highly effective small-molecule inhibitor of glutathione peroxidase 4 (GPX4) with an IC50 value of 0.311 μM, which exerts its pharmacological activity by covalently binding to the Sec46 active site of GPX4, thereby disrupting lipid peroxide detoxification, inducing intracellular Fe²⁺ accumulation, elevating lipid peroxide (LPO) and reactive oxygen species (ROS) levels, triggering ferroptosis-associated DNA damage, demonstrating strong anti-proliferative effects with high ferroptosis selectivity, and providing a robust experimental tool for mechanistic and therapeutic studies in Triple-Negative Breast Cancer (TNBC).

Research Area

Metabolism Research

Key Properties

• CAS Number: 3102894-57-2
• MW: 395.81
• Purity: 99.97% (May vary between batches)
• Formula: C₁₉H₁₉ClFNO₅
• SMILES: O=C(N(C1=CC(OC)=C(F)C(OC)=C1)CC2=CC=C3OCCOC3=C2)CCl
• Target: GPX

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

GPX