gamma-L-Glutamyl-p-nitroanilide HCl

SKU: orb1308261

Description

GPNA hydrochloride is a glutamine transporter ASCT2 (SLC1A5) inhibitor and a known γ-glutamyltransferase (GGT) substrate. It also inhibits SNAT and LAT family amino acid transporters. This compound is widely used in cancer metabolism research, where it induces apoptosis in vitro, such as in A549 lung cancer cell studies.

Research Area

Neuroscience

Key Properties

• CAS Number: 67953-08-6
• MW: 303.70
• Purity: >98%
• Formula: C₁₁H₁₃N₃O₅ · HCl
• SMILES: Cl.NC(=O)CCC(Nc1ccc(cc1)[N+]([O-])=O)C(O)=O
• Target: Glutathione
• Solubility: Soluble in Water (up to 5 mg/ml).

Bioactivity

• In Vitro:
  GPNA hydrochloride is a glutamine transporter ASCT2 inhibitor. GPNA reversibly induces apoptosis in A549 cells. GPNA hydrochloride is a substrate of the enzyme γ-glutamyltransferase (GGT). GPNA hydrochloride also inhibits Na+-dependent carriers.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

GPNA

Compound Identifiers

PubChem CID

73556210