GOT1 inhibitor-1

SKU: orb1217692

Description

GOT1 inhibitor-1 is a novel, potent and non-covalent inhibitor of glutamate oxaloacetate transaminase 1 (GOT1) with an IC50 of 8.2 uM.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 732973-87-4
• MW: 354.83
• Purity: >98% (HPLC)
• Formula: C₁₉H₁₉ClN₄O
• SMILES: O=C(Nc(cc1)ccc1Cl)N(CC1)CCN1c1c(cc[nH]2)c2ccc1
• Target: GOT1
• Solubility: DMSO:120mg/ml(338.19mM; need ultrasonic)

Bioactivity

• In Vitro:
  PDAC tumors are dependent upon a metabolic pathway involving aspartate aminotransferase 1 (glutamate-oxaloacetate transaminase 1 (GOT1)), for the maintenance of redox homeostasis and sustained proliferation. Small molecule inhibitors targeting this metabolic pathway may provide a novel way for cancer research. In the MDH coupled GOT1 enzymatic assay, GOT1 inhibitor-1 shows an inhibitory effect on GOT1 activity with an IC50 value of 8.2 uM.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

GOT1 inhibitor 2c

Quick Database Links

Gene Symbol

GOT1