Gossypin

SKU: orb1297351

Description

Gossypin

Research Area

Cell Biology, Epigenetics & Chromatin, Molecular Biology, Protein Biochemistry, Signal Transduction

Key Properties

• CAS Number: 652-78-8
• MW: 480.38
• Purity: 98.97% (May vary between batches)
• Formula: C₂₁H₂₀O₁₃
• SMILES: OC[C@H]1O[C@@H](Oc2c(O)cc(O)c3c2oc(-c2ccc(O)c(O)c2)c(O)c3=O)[C@H](O)[C@@H](O)[C@@H]1O
• Target: NF-κB|||S6 Kinase
• Solubility: DMSO:150 mg/mL (312.25 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.16 mM)

Bioactivity

• In Vitro:
  Gossypin is a flavone extracted from Hibiscus vitifolius, which has been reported to exhibit anti-inflammatory, antioxidant, and anticancer activities. However, the anticancer properties of gossypin and its molecular mechanism of action against gastric cancer have not been fully investigated. gossypin is an Aurora kinase A (AURKA) and RSK2 inhibitor that suppresses gastric cancer growth. Gossypin attenuated anchorage-dependent and anchorage-independent gastric cancer cell growth as well as cell migration. Based on the results of in vitro screening and cell-based assays, gossypin directly binds to and inhibits AURKA and RSK2 activities and their downstream signaling proteins. Gossypin decreased S phase and increased G2/M phase cell cycle arrest by reducing the expression of cyclin A2 and cyclin B1 and the phosphorylation of the CDC protein. Additionally, gossypin also induced intrinsic apoptosis by activating caspases and PARP and increasing the expression of cytochrome c. Gossypin is an AURKA and RSK2 inhibitor that could be useful for treating gastric cancer.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

RSK2, S6 Kinase, S6Kinase, cardiovascular,osteoclastogenesis, Beta Amyloid, Anticancer, Antiallergic, Antiinflammatory, Antioxidant, Antiviral, Analgesic, Gossypin, Inhibitor, inhibit, NF-κB, Nuclear factor-κB, Nuclear factor-kappaB, NF-kB, NFkB, NFκB, p65

Compound Identifiers

PubChem CID

5281621