Gossypetin

SKU: orb1684559

Description

Gossypetin

Research Area

Infectious Disease & Virology, Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 489-35-0
• MW: 318.24
• Purity: 95.00% (May vary between batches)
• Formula: C₁₅H₁₀O₈
• SMILES: Oc1ccc(cc1O)-c1oc2c(O)c(O)cc(O)c2c(=O)c1O
• Target: p38 MAPK,MEK,MAPK,Antioxidant,Antibacterial

Bioactivity

• In Vivo:
  Gossypetin (100 mg/kg; p.o.; 5 times a week; for 21 days; (SCID) female mice) leads to a notable reduction in the growth volume of esophageal tumors, while not causing a significant decline in body weight. Moreover, Gossypetin induces a notable decrease in Ki67 expression. Observable morphological distinctions between mouse tissues in treated and untreated groups were absent. Furthermore, Gossypetin treatment strongly suppresses the phosphorylation of p38, an immediate downstream protein of MKK3/6.
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• In Vitro:
  Gossypetin (60 μM; 3 h; KYSE30 and KYSE410 cells) strongly inhibits p38 activity in a dose-dependent manner and demonstrates that Gossypetin directly inhibits MKK3 or MKK6 activity. Gossypetin (20-60 μM; 48 h; KYSE30, KYSE450, and KYSE510 cells) strongly inhibits anchorage-dependent esophageal cancer cell growth in a dose-dependent manner. Gossypetin (20-40 μM; 48 h; KYSE450 and KYSE510 cells) reduces the S phase and induces cell cycle arrest in the G2 phase in a dose-dependent manner. Gossypetin (20-40 μM; 72 h; esophageal carcinoma cells) induces intrinsic apoptosis in esophageal carcinoma cells.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ATPase, Antioxidant, Bacterial, MKK3, MKK6, MMP, Gossypetin, PI3K, p38MAPK, p38, p38 MAPK

Compound Identifiers

PubChem CID

5280647