Goserelin acetate

SKU: orb1223293

Description

Goserelin acetate is a synthetic long-acting agonist of gonadotropin-releasing hormone, used in treatments of cancer.(In Vitro):Goserelin (1 nM-1 mM; 48-72 hours) promotes EOC cell apoptosis.Goserelin (100 μM; 24-72 hours) regulates the expression of human apoptosis-related genes in SKOV3-ip cells.Goserelin (100 μM; 24-72 hours) promotes EOC cell apoptosis by upregulating FOXO1 through the PI3K/AKT signaling pathway.(In Vivo):Goserelin (100 μg; s.c.; daily; for 19 days) significantly increases the proportion of apoptotic cells in the subcutaneous xenograft tumors.

Key Properties

• CAS Number: 145781-92-6
• MW: 1329.46
• Purity: >98% (HPLC)
• Formula: C₆₁H₈₈N₁₈O₁₆
• SMILES: CC(C)C[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)NNC(=O)N)NC(=O)[C@@H](COC(C)(C)C)NC(=O)[C@H](Cc1ccc(cc1)O)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCC(=O)N1.CC(=O)O
• Target: GNRHR
• Solubility: DMSO : ≥ 28 mg/mL; 21.06 mM

Bioactivity

• In Vivo:
  Animal model: Five-week-old specific-pathogen free (SPF) female nude mice (18-20 g), subcutaneous xenograft tumor model. Dosage: 100 μg/mice. Administration: Subcutaneous injection, daily, for 19 days. Result: Significantly increased the proportion of apoptotic cells in the subcutaneous xenograft tumors.
• In Vitro:
  Apoptosis Analysis Cell line: SKOV3 cells, SKOV3-ip cells, A2780 cells (human EOC cell lines). Concentration: 1 nM, 10 nM, 100 nM, 1 μM, 10 μM, 100 μM, 1 mM. Incubation time: 48 hours, 72 hours. Result: Significantly increased the total apoptosis rate of SKOV3-ip, SKOV3 and A2780 cells. Western blot analysis. Cell line: SKOV3 cells, SKOV3-ip cells, A2780 cells (human EOC cell lines). Concentration: 1 nM, 10 nM, 100 nM, 1 μM, 10 μM, 100 μM, 1 mM. Incubation time: 48 hours, 72 hours. Result: The expression of cleaved-caspase-3 and cleaved-PARP were observably increased at 100 μM. RT-PCR Cell line: SKOV3-ip cells. Concentration: 100 μM. Incubation time: 24 hours, 48 hours, 72 hours. Result: Expression of human apoptosis-related genes regulated

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ICI-118630 acetate

Quick Database Links

Gene Symbol

GNRHR