Golgicide A

SKU: orb1300701

Description

Golgicide A is a potent and rapidly reversible inhibitor of the guanine nucleotide exchange factor GBF1. This small molecule is a valuable research tool for studying Golgi structure, secretory trafficking, and the role of ARF signaling in both cellular and animal models of infection and secretion.

Research Area

Infectious Disease & Virology

Key Properties

• CAS Number: 1139889-93-2
• MW: 284.3
• Purity: 99.93% (May vary between batches)
• Formula: C₁₇H₁₄F₂N₂
• SMILES: Fc1cc(F)c2NC([C@@H]3CC=C[C@@H]3c2c1)c1cccnc1
• Target: Virus Protease
• Solubility: DMSO:14.2 mg/mL (49.95 mM)

Bioactivity

• In Vitro:
  Golgicide A inhibits the effect of shiga toxin on protein synthesis with an IC50 of 3.3 μM. Golgicide A causes a decrease in GBF1-mediated Arf1 activation, arrests secretion of soluble and membrane-anchored proteins and then impairs retrograde toxin transport. Golgicide A decreases HCV RNA levels in FLRP1 cells and J6/JFH1 cells. In addition, Golgicide A causes redistribution of NS5A and accumulation of infectious viral particles in J6/JFH1 cells.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Inhibitor, GCA, GBF1, HEV, HEVs, HRV, HRVs, Golgicide A, Enterovirus, Rhinovirus, VirusProtease, Virus Protease

Compound Identifiers

PubChem CID

25113626