Go 6983

SKU: orb1300878

Description

Go 6983

Research Area

Epigenetics & Chromatin, Signal Transduction

Key Properties

• CAS Number: 133053-19-7
• MW: 442.51
• Purity: 99.85%
• Formula: C₂₆H₂₆N₄O₃
• SMILES: COc1ccc2n(CCCN(C)C)cc(C3=C(C(=O)NC3=O)c3c[nH]c4ccccc34)c2c1
• Target: PKC
• Solubility: 5% DMSO+40% PEG400+5% Tween80+50% Saline:10 mg/mL (22.6 mM);DMSO:22.1 mg/mL (49.94 mM)

Bioactivity

• Target IC50:
  PKCδ:10 nM|PKCζ:60 nM|PKCμ:20000 nM|PKCβ:7 nM|PKCγ:6 nM|PKCα:7 nM
• In Vivo:
  METHODS: To study the antitumor activity of Go 6983, MDA-MB-231 cells or PBS were injected into the humeral metaphysis of each mouse, and 14 days later Go 6983 (2.5 and 5 mg/Kg) was injected intraperitoneally to nude mice for 28 days. RESULTS: Go 6983 inhibited osteolysis in breast cancer cells.
• In Vitro:
  METHODS: A375, SK-MEL-28, and mouse B16-F10 cells were treated with Go 6983 (0, 0.625, 1.25, 2.5, 5, 10, 20 or 40 μM) for 24, 48, and 72 hours, and the cell growth inhibition was detected by ELISA assay. RESULTS: The IC50 values of Go 6983, Go 6983 (Go 6983) at 24, 48 and 72 hours were 58.64, 22.07 and 12.93 μM, respectively.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Protein kinase C, PKCζ, PKCδ, PKCγ, PKCα, PKCβ, PKC, inhibit, Inhibitor, Go6983, Go-6983, Go 6983, Goe6983, Goe-6983, Goe 6983, G? 6983

Compound Identifiers

PubChem CID

3499