GNF351

SKU: orb1219527

Description

GNF351 is a full antagonist of the aryl hydrocarbon receptor (AHR)with the capacity to inhibit both DRE-dependent and -independent activity. GNF351 is minimal toxicity in mouse or human keratinocytes. GNF351 competes with a photoaffinity AHR ligand for binding to the AHR (IC50: 62 nM). After treating proliferating monolayer cultures of human keratinocytes, GNF351 (500 nM, 48 hours) obviously decreases the percentage of Ki67-positive cells and cell number.

Key Properties

• CAS Number: 1227634-69-6
• MW: 411.5
• Purity: >98% (HPLC)
• Formula: C₂₄H₂₅N₇
• SMILES: CC(C)n1cnc2c(NCCc3c[nH]c4ccccc34)nc(nc12)-c1cncc(C)c1
• Target: aryl hydrocarbon receptor
• Solubility: DMSO:124 mg/mL(301.34 mM)

Bioactivity

• In Vitro:
  Cell Proliferation Assay Cell line: Human primary keratinocytes. Concentration: 500 nM. Incubation time: 48 hours. Result: Showed a significant reduction in the percentage of Ki67-positive cells and cell number after treating proliferating monolayer cultures of human keratinocytes for 48 hours.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

aryl hydrocarbon receptor