GNF-6

• Catalog Number: orb2566167
• Category: Small Molecules
• Description: GNF-6 (Compound 14), an ATP competitive inhibitor, inhibits the gatekeeper threonine residue mutation of BCR-ABL-T315I with IC50 values of 0.25 μM for c-ABL-T334I, 0.09 μM for BCR-ABL, and 0.590 μM for BCR-ABL-T315I variants. It disrupts the assembly of the hydrophobic spine (a network of hydrophobic interactions), locking the kinase in an inactive 'DFG-out' conformation.
• MW: 456.42
• CAS Number: 839708-29-1
• Formula: C₂₂H₁₉F₃N₆O₂
• SMILES: O=C1N(CC=2C(N1C)=NC(N)=NC2)C3=CC(NC(=O)C4=CC(C(F)(F)F)=CC=C4)=CC=C3C
• Storage: -20°C
• Note: For research use only
• Expiration Date: 12 months from date of receipt.