GNF-351

• Catalog Number: orb746446
• Category: Small Molecules
• Description: GNF-351 is a potent, pure aryl hydrocarbon receptor (AHR) antagonist (IC50=62 nM) devoid of partial agonist potential; antagonizes agonist and SAhRM-mediated suppression of SAA1, inhibit both DRE-dependent and -independent activity; decreases migration and invasion of HNSCC cells and prevents benzo[a]pyrene-mediated induction of the chemotherapy efflux protein ABCG2.
• MW: 411.5
• Formula: C₂₄H₂₅N₇
• SMILES: N1C2C(=NC(C3=CC(C)=CN=C3)=NC=2NCCC2C3=C(N=C2)C=CC=C3)N(C(C)C)C1
• Note: For research use only