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GNE-7915

SKU: orb1226475

Description

A highly potent, selective, and brain-penetrant LRRK2 inhibitor with IC50 of 1.9 nM; shows 1/187 kinases with 50% inhibition at 0.1 uM; possesses an ideal balance of LRRK2 cellular potency, broad kinase selectivity, metabolic stability, and brain penetration across multiple species.Parkinson's Disease Preclinical.

Images & Validation

Key Properties

CAS Number1351761-44-8
MW443.3954
Purity>98% (HPLC)
FormulaC19H21F4N5O3
SMILESO=C(C1=CC(OC)=C(NC2=NC=C(C(F)(F)F)C(NCC)=N2)C=C1F)N3CCOCC3
TargetLRRK2
SolubilityDMSO: 14.33 mg/mL

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

GNE7915 | GNE 7915

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GNE-7915 (orb1226475)

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Available Sizes

Select a size below

5 mg
$ 80.00
10 mg
$ 100.00
25 mg
$ 180.00
50 mg
$ 280.00
100 mg
$ 460.00
200 mg
$ 580.00
500 mg
$ 940.00