GNE-7883

SKU: orb2278540

Description

GNE-7883 is a small molecule TEAD inhibitor that suppresses YAP/TAZ oncogenic signaling. It is a valuable research tool for investigating Hippo pathway-dependent cancers in both cellular and animal models, demonstrating efficacy in reducing tumor cell proliferation.

Research Area

Stem Cell & Developmental Biology

Key Properties

• CAS Number: 2648450-42-2
• MW: 500.57
• Purity: 99.38% (May vary between batches)
• Formula: C₂₈H₂₉FN₆O₂
• SMILES: O=C1C=C(NC2=C(C(=O)N3CC(CF)C3)C(=NN12)C=4N=CC=NC4C)C=5C=CC(=CC5)C6CCCCC6
• Target: YAP
• Solubility: DMSO:30 mg/mL (59.93 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

GNE 7883, GNE7883, YAP, TEAD

Compound Identifiers

PubChem CID

164852436