GNE-618

SKU: orb1707257

Description

GNE-618 is a potent, orally bioavailable inhibitor of nicotinamide phosphoribosyltransferase (NAMPT) with an IC50 of 6 nM. It depletes cellular NAD+, leading to tumor cell death, and has demonstrated anti-tumor activity in both in vitro and in vivo cancer research models.

Research Area

Metabolism Research

Key Properties

• CAS Number: 1362151-42-5
• MW: 460.43
• Formula: C₂₁H₁₅F₃N₄O₃S
• SMILES: FC(F)(F)c1cccc(c1)S(=O)(=O)c1ccc(CNC(=O)c2cnc3[nH]ncc3c2)cc1
• Target: NAMPT

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

66613669