GNE-5472

SKU: orb3177237

Description

GNE-5472 is a potent dual-function ERαPRRTAC degrader featuring an E3 ligase ligand that acts as a pan-IAP antagonist. By antagonizing cIAP1/2, GNE-5472 activates the non-canonical NF-κB pathway, resulting in a significant upregulation of TNFα expression. It inhibits the proliferation of breast cancer cells and induces apoptosis. GNE-5472 is applicable in breast cancer research.

Key Properties

• CAS Number: 2417369-99-2
• MW: 1056.33
• Formula: C₅₉H₇₃N₇O₉S
• SMILES: C(=C(CC)C1=CC=CC=C1)(C2=CC=C(OCCN(C(CCOCCOCCC(NC3=NC(=C(NC(=O)[C@H]4N(C([C@@H](NC([C@@H](NC)C)=O)C5CCCCC5)=O)CCC4)S3)C6=CC=CC=C6)=O)=O)C)C=C2)C7=CC=C(O)C=C7
• Target: Apoptosis,Estrogen Receptor/ERR,TNF,PROTACs,IAP,NF-κB

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Apoptosis,Estrogen Receptor/ERR,TNF,PROTACs,IAP,NF-κB