GNE-493

SKU: orb1300013

Description

GNE-493

Research Area

Signal Transduction

Key Properties

• CAS Number: 1033735-94-2
• MW: 372.44
• Purity: 98.00% (May vary between batches)
• Formula: C₁₇H₂₀N₆O₂S
• SMILES: CC(C)(O)c1cc2nc(nc(N3CCOCC3)c2s1)-c1cnc(N)nc1
• Target: PI3K|||mTOR
• Solubility: DMSO:45 mg/mL (120.82 mM)

Bioactivity

• Target IC50:
  PI3Kδ:16 nM |PI3Kβ:12 nM |PI3Kα:3.4 nM |mTOR:32 nM|PI3Kγ:16 nM
• In Vivo:
  GNE-493 was tested in a human MCF7.1 breast cancer xenograft model with a PI3Kα activating mutation. Mice with xenografts received a daily oral dose of 10 mg/kg of GNE-493 for 21 continuous days. Comparable to results in the PC3 prostate cancer model, this treatment led to a 73% inhibition of tumor growth by day 21 compared to control. With similar drug exposure levels, GNE-493 demonstrated equivalent suppression of the PI3K pathway and, thus, comparable efficacy against MCF7.1 breast tumors.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PI3K, Phosphoinositide 3-kinase, mTOR, inhibit, GNE 493, GNE493, GNE-493, Inhibitor, Mammalian target of Rapamycin

Compound Identifiers

PubChem CID

25242324