GNE-490

SKU: orb1305991

Description

GNE-490 is a potent and selective pan-PI3K inhibitor, exhibiting low nanomolar IC50 values against PI3Kα, β, δ, and γ isoforms while showing over 200-fold selectivity over mTOR. This profile makes it a valuable chemical probe for investigating PI3K pathway biology in cancer and immunological research, both in vitro and in vivo.

Research Area

Signal Transduction

Key Properties

• CAS Number: 1033739-92-2
• MW: 386.47
• Purity: 99.77%
• Formula: C₁₈H₂₂N₆O₂S
• SMILES: Cc1nc(N)ncc1-c1nc(N2CCOCC2)c2sc(cc2n1)C(C)(C)O
• Target: PI3K,mTOR
• Solubility: DMSO:50 mg/mL (129.38 mM)

Bioactivity

• Target IC50:
  PI3Kγ:15 nM|mTOR:750 nM|PI3Kα:3.5 nM|PI3Kβ:25 nM|PI3Kδ:5.2 nM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

GNE 490, GNE490, GNE-490, Inhibitor, MCF7.1, Mammalian target of Rapamycin, inhibit, mTOR, breast cancer, PI3K, PI3Kβ, PI3Kγ, PI3Kα, PI3Kδ, Phosphoinositide 3-kinase

Compound Identifiers

PubChem CID

46180666