GNE-477

SKU: orb1303889

Description

GNE-477 is a small molecule inhibitor that potently and simultaneously targets both PI3K and mTOR kinases. This dual mechanism makes it a valuable research tool for studying oncogenic signaling pathways in cancer research, applicable in both cellular and animal models of tumorigenesis.

Research Area

Signal Transduction

Key Properties

• CAS Number: 1032754-81-6
• MW: 504.63
• Purity: 99.95% (May vary between batches)
• Formula: C₂₁H₂₈N₈O₃S₂
• SMILES: Cc1c(CN2CCN(CC2)S(C)(=O)=O)sc2c(nc(nc12)-c1cnc(N)nc1)N1CCOCC1
• Target: mTOR,PI3K
• Solubility: DMSO:6.88 mg/mL (13.63 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (1.98 mM)

Bioactivity

• Target IC50:
  PI3Kα:4 nM|mTOR:21 nM(Ki app)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

mTOR, inhibit, Inhibitor, Mammalian target of Rapamycin, GNE477, GNE-477, GNE 477, Phosphoinositide 3-kinase, PI3K, PI3Kα

Compound Identifiers

PubChem CID

25207689