GNE-274

SKU: orb1690966

Description

GNE-274 is a structurally related, non-degrading analog of GDC-0927 that functions as a potent ERα LBD inhibitor and partial agonist. Unlike degraders, it increases chromatin accessibility at ER binding sites without inducing receptor turnover, making it a valuable tool for studying ER-driven transcription and resistance mechanisms in breast cancer cell models.

Research Area

Metabolism Research

Key Properties

• CAS Number: 2369048-69-9
• MW: 457.57
• Formula: C₂₉H₃₁NO₄
• SMILES: CCCN1CC(COc2ccc(cc2)[C@@H]2Oc3ccc(O)cc3C(C)=C2c2cccc(O)c2)C1
• Target: Others,Estrogen Receptor/ERR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

162641011