GNE-207

SKU: orb1707260

Description

GNE-207 is a potent, selective, and orally bioavailable CBP bromodomain inhibitor with an IC50 of 1 nM, demonstrating >2500-fold selectivity over BRD4. It effectively reduces MYC expression in MV-4-11 cells (EC50 = 18 nM) and is a valuable chemical probe for studying CBP/EP300 biology in cancer and other disease research.

Research Area

Epigenetics & Chromatin

Key Properties

• CAS Number: 2158266-58-9
• MW: 510.59
• Formula: C₂₉H₃₀N₆O₃
• SMILES: CNC(=O)c1ccc(cn1)-c1cc2cccc(-c3nn(C4CCOCC4)c4CCN(Cc34)C(C)=O)c2cn1
• Target: Epigenetic Reader Domain,Histone Acetyltransferase

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

132186469