GNE-131

SKU: orb1296271

Description

GNE-131

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1629063-81-5
• MW: 442.57
• Purity: 99.73%
• Formula: C₂₃H₃₀N₄O₃S
• SMILES: O=S(=O)(Nc1nnc2cc(OCC34CC5CC(CC(C5)C3)C4)c(cn12)C1CC1)C1CC1
• Target: Sodium Channel
• Solubility: DMSO:120 mg/mL (271.14 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (9.04 mM)

Bioactivity

• Target IC50:
  Nav1.7 channel:3 nM (cell free)
• In Vivo:
  GNE-131 demonstrates low in vivo clearance in dogs, rats, and mice, and exhibits excellent efficacy in a transgenic mouse model of induced pain.
• In Vitro:
  GNE-131 shows moderate clearance in human liver microsomes and excellent functional activity against human NaV1.7 IC50 0.003 μM).

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

SodiumChannel, Sodium Channel, Na+ channels, Na channels, Nav1.7 channel, NaV1.7, inhibit, Inhibitor, GNE131, GNE-131, GNE 131

Compound Identifiers

PubChem CID

91666633