GNE-0749

SKU: orb1818742

Description

GNE-0749 is a potent and selective pan-RAF inhibitor with Ki of 0.061 nM and <0.08 nM for CRAF and BRAF, respectively. Combinated with cobimetinib, GNE-0749 demonstrates synergistic pharmacodynamic effects in the KRAS mutant HCT116 tumor-bearing mice.

Key Properties

• MW: 443.5
• Purity: >98%
• Formula: C₂₃H₂₇F₂N₅O₂
• SMILES: N(CCC(C)(C)C)C(NC1=CC(NC2C=CC3=C(C=2F)C(=O)N(C)C=N3)=C(C)C=C1F)=O

Storage & Handling

• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

155920150