GN44028

SKU: orb1308267

Description

GN44028 is a potent small molecule inhibitor of hypoxia-inducible factor 1 (HIF-1) with an IC50 of 14 nM. It specifically blocks hypoxia-induced HIF-1α transcriptional activity without affecting its mRNA, protein levels, or heterodimerization. This compound is a valuable research tool for studying hypoxia signaling in cancer and other diseases in cellular models.

Research Area

Cardiovascular Research, Epigenetics & Chromatin, Metabolism Research

Key Properties

• CAS Number: 1421448-26-1
• MW: 305.33
• Purity: 99.52% (May vary between batches)
• Formula: C₁₈H₁₅N₃O₂
• SMILES: C1c2ccccc2-c2[nH]nc(Nc3ccc4OCCOc4c3)c12
• Target: HIF,HIF/HIF Prolyl-Hydroxylase
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.55 mM);DMSO:44 mg/mL (144.11 mM)

Bioactivity

• Target IC50:
  HIF1:14 nM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

cancer, colorectal cancer, PN12, N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine, inhibit, Hypoxia-inducible factors, Hypoxia, heterodimerization, HIF-1, HIF-PH, HIFs, HIF/HIF Prolyl-Hydroxylase, HeLa, HCT116, Inhibitor, ME23, GSCs, GN 44028, GN44028, GN-44028

Compound Identifiers

PubChem CID

71625259