GlyH-101

SKU: orb1225300

Description

A potent CFTR inhibitor with Ki of 4.3 uM; rapidly and reversibly inhibited forskolin-induced hyperpolarization in nasal potential differences in mice; effectively reduces cholera toxin-induced intestinal fluid secretion in a closed-loop model of cholera.

Key Properties

• CAS Number: 328541-79-3
• MW: 493.1487
• Purity: >98% (HPLC)
• Formula: C₁₉H₁₅Br₂N₃O₃
• SMILES: O=C(N/N=C/C1=C(O)C(Br)=C(O)C(Br)=C1)CNC2=CC3=CC=CC=C3C=C2
• Target: CFTR
• Solubility: DMSO: ≥ 58 mg/mL

Bioactivity

• In Vivo:
  GlyH-101 (2.5 μg) reduces by about 80% cholera toxin-induced intestinal fluid secretion in mouse.
• In Vitro:
  GlyH-101 (0-50 μM) shows antiproliferative activity in PCT and PS120 cells. GlyH-101 (0.5, 1, 5, 10 μM) inhibits CFTR-like current in a concentration-dependent manner in PCT cells. GlyH-101 (0.5, 1, 5, 10 μM) inhibits the VSORC current with IC50s of 5.38, 6.26 μM for PS120, PCT cells, respectively. Cell Viability Assay Cell line: PCT, PS120 cells. Concentration: 0, 1, 5, 10, 20, 50 μM. Incubation time: 24 h. Result: Inhibited the cell growth in a dose-dependent manner.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

GlyH 101 | GlyH101

Quick Database Links

Gene Symbol

CFTR