Glycyl-L-Histidyl-L-Lysine

SKU: orb1222172

Description

Glycyl-L-histidyl-L-lysine is a liver cell growth factor and an asynthetic hepatotrophic agent that stimulates hepatic erythropoietic factor production.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 49557-75-7
• MW: 340.38
• Purity: >98% (HPLC)
• Formula: C₁₄H₂₄N₆O₄
• SMILES: NCCCC[C@H](NC(=O)[C@H](CC1=CN=CN1)NC(=O)CN)C(O)=O
• Target: Others
• Solubility: In Vitro: H2O : 100 mg/mL (293.79 mM)

Bioactivity

• In Vivo:
  Glycyl-L-histidyl-L-lysine (intraperitoneal injection; 1.5, 5, 50, 150, and 450 mg/kg; 10 times) can stimulate mitotic activity of hepatocytes and dose-dependently suppresse immune reactivity. Glycyl-L-histidyl-L-lysine (intraperitoneal injection; 0.5, 5, and 50 μg/kg) can produce an anxiolytic effect in the elevated plus maze test.
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• In Vitro:
  Glycyl-L-histidyl-L-lysine and its copper complexes and saccharomyces/copper ferment on secretion of pro-inflammatory IL-6 in normal human dermal fibroblasts NHDF cell line. Glycyl-L-histidyl-L-lysine and its copper complexes decreases TNF-α-dependent IL-6 secretion in fibroblasts.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Others