Glycogen phosphorylase-IN-1

SKU: orb1692772

Description

Glycogen phosphorylase-IN-1 is a potent and selective inhibitor of human liver glycogen phosphorylase (hlGPa). It effectively reduces hlGPa enzymatic activity and suppresses glycogenolysis in hepatocytes, making it a valuable research tool for investigating type 2 diabetes and related metabolic disorders in both cellular and animal models.

Research Area

Metabolism Research

Key Properties

• CAS Number: 648926-15-2
• MW: 412.78
• Purity: 99.16% (May vary between batches)
• Formula: C₁₇H₁₅ClF₂N₄O₄
• SMILES: O=C(NC(=O)C1=CC(F)=C(F)C=C1Cl)NC2=CC(=CC=C2OC)NC(=O)NC
• Target: Phosphorylase,Others
• Solubility: DMSO:2 mg/mL (4.85 mM);DMF:2 mg/mL (4.85 mM)

Bioactivity

• In Vivo:
  In the glucagon-stimulated hyperglycemia model in Wistar rats, Glycogen phosphorylase-IN-1 (5 mg/kg; administered via intravenous injection, single dose) was able to reduce blood glucose levels.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Glycogen phosphorylase (GP), Glycogen Phosphorylase Inhibitor

Compound Identifiers

PubChem CID

10070301